You need to switch the command interface to Thunderbolt™ from the System Menu of Orion Studio by holding the top right button and navigating to “Comm Interface” using the Front Panel knob. Select Thunderbolt by pressing the knob.
If your computer is running on Catalina or Bug Sur, you will have to allow the unified driver from security and privacy.
If your computer is running on Catalina or Bug Sur, you will have to allow the unified driver from security and privacy.
If your not sure how to do that, please check the article below:
https://support.antelopeaudio.com/support/solutions/articles/42000079813-how-to-allow-the-installation-of-antelope-unified-driver-on-macos-10-15-catalina
If you have an M1 configuration, please check the article below to make sure kernel extensions are allowed:
https://en.antelopeaudio.com/2021/02/m1-antelope-compatibility/